MGF Growth Hormone Peptides IGF - 1 Ec Mechano Growth For Bodybuilding

Growth Hormone Peptides MGF IGF-1Ec 2mg MGF 5mg Inection Powder For Muslc Growth

MGF Basic Info

Name: MGF

M.F.: C121H200N42O39
Purity (HPLC): 98.0%
Single Impurity(HPLC): 0.5%max.
Amino Acid Composition: about 10% of theoretical
Peptide Content(N%): 80.0%min.
Water Content(Karl Fischer): 8.0%max.
Acetate Content(HPLC):10.0%max.
Specific Rotation: (20/D) -55.0 ~ -65.0 dgree(c=1 1%HAc)
MS(ESI): Consistent
Mass Balance: 95.0~105.0%
Bacterial Endotoxins: 5 EU/mg max.
Appearance: White powder
Function: Promotion Development Dosage
Form: Powder
Active Substance: It is PEGylated MGF
Application: PEGylation is the act of attaching a Polyethylene glycol (PEG) structure to another larger molecule (in this case, MGF). The PEG acts as a protective coating and the theory here is that this will allow the MGF to be carried through the blood stream without being broken down.

MGF Description

Mechano growth factor, also known as MGF or IGF-1Ec, is a locally expressed splice variant of IGF-1. It is generated on a cellular level and plays a key role in the growth factor cascades of pubery and post-exercise. MGF binds to IGF receptors and acts as a cell proliferator primarily:

The physiological function of a recently cloned splice variant of insulin-like growth factor-I (IGF-I; mechano growth factor (MGF)) was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected.

MGF Application

After resistance exercise, IGF-1 is released within the muscle. Specifically, at this time, immediately following the mechanical use of a muscle, the IGF-I gene is spliced towards MGF which initiates hypertrophy and repair of local muscle damage. It does so both by activating muscle stem cells and satellite cells, but also via various other anabolic processes.It differs from “regular” IGF-1 mainly due to it’s C-Terminal sequence.

When mechanical overload is introduced to a muscle (as by weight training), the IGF-1 gene released and is differentially spliced during the bodies response. Initially, it it is spliced to produce predominantly IGF-1Ec (called the MGF splice variant of IGF-1). This early splicing stimulates satellite cells into activation. Which in turn allows the activation of extra undamaged nuclei to grow new muscle fiber and tissue.

The appearance of MGF also initiates the upregulation of new protein synthesis. After this initial splicing of IGF-1 into MGF, production then switches towards producing a systemic release of IGF-1Ea from the liver, which also upregulates protein synthesis as well. The expression of IGF-1 splice variants, over the course of the healing and regrowth phase of muscle repair is thought to be the primary anabolic mechanism by which the body produces new muscle. MGF is available as an injectable peptide, and it has been anecdotally shown that injecting it will cause a response in the area resulting in localized muscle growth.

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